STIM1/Orai1-mediated store-operated Ca2+ entry: the tip of the iceberg

STIM1/Orai1-mediated store-operated Ca2+ entry: the tip of the iceberg

Blog Article

Highly efficient mechanisms regulate intracellular calcium (Ca2+) levels.The recent discovery of new components linking intracellular Ca2+ stores to plasma membrane Ca2+ entry channels has brought new insight into the understanding of Ca2+ homeostasis.Stromal interaction molecule 1 (STIM1) was identified as a Ca2+ sensor essential for Ca2+ store depletion-triggered Ca2+ influx.

Orai1 was recognized as Oil Test Strips being an essential component for the Ca2+ release-activated Ca2+ (CRAC) channel.Together, these proteins participate in store-operated Spray Arm Bush Ca2+ channel function.Defective regulation of intracellular Ca2+ is a hallmark of several diseases.

In this review, we focus on Ca2+ regulation by the STIM1/Orai1 pathway and review evidence that implicates STIM1/Orai1 in several pathological conditions including cardiovascular and pulmonary diseases, among others.